Description
What TEMOTIZ is ?
TEMOTIZ is a cancer medicine used in the treatment of
a d u l t p a t i e n t s w i t h n e w l y – d i a g n o s e d
glioblastomamultiforme concomitantly with
radiotherapyand subsequently as monotherapy
treatment. Children from the age of three years,
adolescents and adult patients with malignant glioma,
such as glioblastomamultiforme or anaplastic
astrocytoma, showing recurrence or progression after
standard therapy.
How TEMOTIZ works?
TEMOTIZhard capsules should be administered in the
fasting state.The capsules must be swallowed whole
with a glass of water and must not be opened or
chewed.If vomiting occurs after the dose is administered,
a second dose should not be administered that day.
How to take TEMOTIZ?
TEMOTIZis a triazene, which undergoes rapid chemical
conversion at physiologic pH to the active
monomethyltriazenoimidazolecarboxamide. The
cytotoxicity of MTIC is thought to be due primarily to
alkylation at the O6 position of guanine with additional
alkylation also occurring at the N7 position. Cytotoxic
lesions that develop subsequently are thought to involve
Temozolomide Capsules 250 mgaberrant repair of the methyl adduct.
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